BernheimV1, Main, Exploration, bibRecord, 000068

Physico-chemistry of lipopolysaccharides and inflammatory response : role of lipoproteins

Identifieur interne : 000068 ( Main/Exploration ); précédent : 000067; suivant : 000069

Physico-chemistry of lipopolysaccharides and inflammatory response : role of lipoproteins

Auteurs : Wahib Sali [France]

Source :

RBID : Hal:tel-01134149

Descripteurs français

mix :
- Agrégation, Dosage LC-MS/MS, Immunité innée, Inflammation, Lipide A, Lipopolysaccharide (LPS), Lipoprotéine, Monocyte, Protéine de Transfert des Phospholipides (PLTP), TLR4 (Toll-Like Receptor 4).

English descriptors

mix :
- Aggregation, Innate immunity, LC-MS/MS assay, Lipoprotein, PhosphoLipid Transfer Protein (PLTP).

Abstract

LPS is a potent bacterial pro-inflammatory agent, consisting of hydrophilic, polysaccharide part and of a lipid A which is considered like active moiety. Nevertheless, the O chain of LPS influences their aggregation in aqueous media. Therefore, our goal has been to determine the role of O chain on the LPS biological and physiopathological effects. Our work was organized according to three main axes, and led to the following findings :- development of a new LPS assay by LC-MS/MS. The combination of this new technique with LAL test allowed us to calculate an inactivation ratio which reflects the ability of host organism to inactivate LPS, especially through their transfer to HDL by PLTP. The ratio could be useful in predicting outcome of high risk patients.- the length of O chain modulates LPS-induced inflammation. Above their critical aggregation concentration, LPS form aggregates with an architecture and physiochemical properties dependent on their O chain. Both parameters determine LPS biological activity and their metabolism.- development of an innovative dual labelling of LPS as a new tool to explore LPS elimination pathway : the reverse LPS transport. This work brings evidence that the physiopathological effects of LPS depend on two parameters : their biological activity and their metabolism. Any strategy of research or therapeutic targeting LPS should take into account their molecular structure, their aggregability and the relation between the both parameters, which are major determinants of their biological activity and their metabolism.

Url:

https://tel.archives-ouvertes.fr/tel-01134149

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000110
to stream Hal, to step Curation: 000110
to stream Hal, to step Checkpoint: 000062
to stream Main, to step Merge: 000068
to stream Main, to step Curation: 000068

Le document en format XML

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<front><div type="abstract" xml:lang="en">LPS is a potent bacterial pro-inflammatory agent, consisting of hydrophilic, polysaccharide part and of a lipid A which is considered like active moiety. Nevertheless, the O chain of LPS influences their aggregation in aqueous media. Therefore, our goal has been to determine the role of O chain on the LPS biological and physiopathological effects.  Our work was organized according to three main axes, and led to the following findings :- development of a new LPS assay by LC-MS/MS. The combination of this new technique with LAL test allowed us to calculate an inactivation ratio which reflects the ability of host organism to inactivate LPS, especially through their transfer to HDL by PLTP. The ratio could be useful in predicting outcome of high risk patients.- the length of O chain modulates LPS-induced inflammation. Above their critical aggregation concentration, LPS form aggregates with an architecture and physiochemical properties dependent on their O chain. Both parameters determine LPS biological activity and their metabolism.- development of an innovative dual labelling of LPS as a new tool to explore LPS elimination pathway : the reverse LPS transport.  This work brings evidence that the physiopathological effects of LPS depend on two parameters : their biological activity and their metabolism.  Any strategy of research or therapeutic targeting LPS should take into account their molecular structure, their aggregability and the relation between the both parameters, which are major determinants of their biological activity and their metabolism.</div>
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Serveur d'exploration Hippolyte Bernheim

Physico-chemistry of lipopolysaccharides and inflammatory response : role of lipoproteins

Physico-chemistry of lipopolysaccharides and inflammatory response : role of lipoproteins

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri